The association of sensitivity and specificity with disease prevalence: analysis of 6909 studies of diagnostic test accuracy

Evidence-Based Practice Center (Murad, Hasan, Alsibai, Abbas, Wang), Mayo Clinic, Rochester, Minn.; Department of Epidemiology and Biostatistics (Lin), University of Arizona, Tucson, Ariz.; Statistical Research and Data Science Center (Chu), Pfizer, New York, NY; Department of Internal Medicine (Mustafa), University of Kansas Health System, Kansas City, Kan.

Evidence-Based Practice Center (Murad, Hasan, Alsibai, Abbas, Wang), Mayo Clinic, Rochester, Minn.; Department of Epidemiology and Biostatistics (Lin), University of Arizona, Tucson, Ariz.; Statistical Research and Data Science Center (Chu), Pfizer, New York, NY; Department of Internal Medicine (Mustafa), University of Kansas Health System, Kansas City, Kan.

Evidence-Based Practice Center (Murad, Hasan, Alsibai, Abbas, Wang), Mayo Clinic, Rochester, Minn.; Department of Epidemiology and Biostatistics (Lin), University of Arizona, Tucson, Ariz.; Statistical Research and Data Science Center (Chu), Pfizer, New York, NY; Department of Internal Medicine (Mustafa), University of Kansas Health System, Kansas City, Kan.

Evidence-Based Practice Center (Murad, Hasan, Alsibai, Abbas, Wang), Mayo Clinic, Rochester, Minn.; Department of Epidemiology and Biostatistics (Lin), University of Arizona, Tucson, Ariz.; Statistical Research and Data Science Center (Chu), Pfizer, New York, NY; Department of Internal Medicine (Mustafa), University of Kansas Health System, Kansas City, Kan.

Evidence-Based Practice Center (Murad, Hasan, Alsibai, Abbas, Wang), Mayo Clinic, Rochester, Minn.; Department of Epidemiology and Biostatistics (Lin), University of Arizona, Tucson, Ariz.; Statistical Research and Data Science Center (Chu), Pfizer, New York, NY; Department of Internal Medicine (Mustafa), University of Kansas Health System, Kansas City, Kan.

Evidence-Based Practice Center (Murad, Hasan, Alsibai, Abbas, Wang), Mayo Clinic, Rochester, Minn.; Department of Epidemiology and Biostatistics (Lin), University of Arizona, Tucson, Ariz.; Statistical Research and Data Science Center (Chu), Pfizer, New York, NY; Department of Internal Medicine (Mustafa), University of Kansas Health System, Kansas City, Kan.

Evidence-Based Practice Center (Murad, Hasan, Alsibai, Abbas, Wang), Mayo Clinic, Rochester, Minn.; Department of Epidemiology and Biostatistics (Lin), University of Arizona, Tucson, Ariz.; Statistical Research and Data Science Center (Chu), Pfizer, New York, NY; Department of Internal Medicine (Mustafa), University of Kansas Health System, Kansas City, Kan.

Evidence-Based Practice Center (Murad, Hasan, Alsibai, Abbas, Wang), Mayo Clinic, Rochester, Minn.; Department of Epidemiology and Biostatistics (Lin), University of Arizona, Tucson, Ariz.; Statistical Research and Data Science Center (Chu), Pfizer, New York, NY; Department of Internal Medicine (Mustafa), University of Kansas Health System, Kansas City, Kan.